Master Thesis

Evaluation of oxidative biocatalysts for the preparation of drug metabolites


Mehr Jobs von ACIB - Austrian Centre of Industrial Biotechnology
Kontakt: Dr. Margit Winkler
Email: margit.winkler@acib.at
Telefon: 0316-873...

ACIB - the Austrian Centre of Industrial Biotechnology - is one of the leading research centre in the field of industrial biotechnology. ACIB is dedicated to joint research at the industrial-academic interface. 18 Universities and more than 45 industry partners are working together within the ACIB research program. In Graz we currently offer a

Master thesis

on

Evaluation of oxidative biocatalysts for the preparation of drug metabolites

 

The main goal of this project is to develop robust formulations of microbial cells and to use them for the synthesis of drug metabolites. We are mainly working with cytochrome P450 enzymes which are either expressed in E. coli or in Komagataella phaffii (Pichia pastoris). One task is to optimize cultivation conditions, lyophilization conditions and biotransformation conditions. Another task is to determine the activity of the resulting cells for their ability to oxidize pharmaceutical ingredients (well known compounds such as Diclofenac, Ibuprofen and many others) and to establish substrate profiles for each biocatalyst. The third task is to assist in the creation of scientific publications.

 

The ideal master candidate studied molecular biology, biochemistry, chemistry or biotechnology and has very good theoretical and practical knowledge of: microbiological work (culturing bacteria and yeasts on small scale, cell disruption, NuPAGE analysis, activity assays, lyophilization); analytics of small molecules (chromatography, GC, HPLC); bioinformatic tools (BLAST, CLC-workbench); The applicants are expected to be enthusiastic to reach ambitious goals, to learn new techniques and to present their results. We are working in an international environment and are looking for highly motivated candidates with excellent English skills both spoken and written.

Earliest start of the thesis: April 2017 at the Institute of Molecular Biotechnology, Graz University of Technology, Petersgasse 14, 8010 Graz;

If you feel addressed, or you would like to have more information, please contact Dr. Margit Winkler (margit.winkler@tugraz.at).


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